High Quality Zinc Glycinate Food Grade Cas No.7214

Tên sản phẩm: Kẽm Glycinate

Kẽm Glycinate %: 98.0%

Công thức phân tử: Zn (nh2ch2coo) 2

Trọng lượng phân tử: 213.5

Tính chất vật lý hóa học: bột trắng, hơi tan trong nước.

Đặc điểm kỹ thuật chất lượng: Sản phẩm thông qua tiêu chuẩn Q/JDH.05-2006.

Kẽm Glycinate là thế hệ thứ ba của phụ gia thức ăn khoáng chất. Nó được sản xuất với một ion kim loại liên kết với một phân tử glycine tạo thành hợp chất vòng với cấu trúc thích hợp. Hợp chất Vòng hữu cơ này rất ổn định khi đi qua môi trường dễ bay hơi trước khi ruột cho phép kẽm hữu cơ đạt được các cơ quan mục tiêu và các mô để tối đa hóa việc sử dụng các khoáng chất vi lượng. Tại các cơ quan hoặc mô đích, Glycinate kẽm được hấp thụ như một phân tử toàn bộ bằng đường dẫn peptide và đường dẫn axit amin. Trong khi đó, ion kim loại được gắn vào một phân tử hoàn chỉnh và Điều này làm giảm các chức năng đối kháng. Khả dụng sinh học tốt nhất của kẽm đã được đảm bảo tốt như tất cả đã đề cập ở trên.

Mặt khác, farmkemi kẽm Glycinate cung cấp ít làm hỏng các thành phần dinh dưỡng khác trong thức ăn như vitamin, protein, vv Nó cũng cung cấp độ ngon tốt hơn. Chúng đã cải thiện chất lượng thức ăn và hiệu quả thức ăn.

Phân bón hóa học được sử dụng để loại bỏ carbon dioxide công nghiệp của dung môi. Ngành công nghiệp Dược phẩm mycophenolate rối cho bộ đệm, chất axit amin để chuẩn bị l-dopa và các loại thuốc khác, ngành công nghiệp thực phẩm được sử dụng làm chất gia vị, Saccharin, mặc dù Đại lý cho việc sản xuất bia, chế biến thịt, chuẩn bị đồ uống ướp lạnh. Ngoài ra, giá trị pH có thể được sử dụng như một bộ điều chỉnh và để chuẩn bị dung dịch mạ điện như vậy.

Zinc Amino Acid Chelates Having Ligands Comprised Of Glycine And A Sulfur

FIELD OF THE INVENTION

The present invention relates to amino acid chelates comprised of zinc, a sulfur-containing amino acid, and glycine having a ligand to metal molar ratio from about 1:1 to 2:1. By adding glycine and a sulfur-containing amino acid as a ligand mixture, a desired zinc weight percentage may be more easily achieved and the zinc becomes more bioavailable than traditional zinc sources.

BACKGROUND OF THE INVENTION

Amino acid chelates are generally produced by the reaction between α-amino acids and metal ions having a valence of two or more to form a heterocyclic ring structure. In such a reaction, the positive electrical charge of the metal ion is neutralized by the electrons available through the carboxylate or free amino groups of the α-amino acid.

Traditionally, the term “chelate” has been loosely defined as a combination of a metallic ion bonded to one or more ligands forming heterocyclic ring structures. Under this definition, chelate formation through neutralization of the positive charges of the divalent metal ions may be through the formation of ionic, covalent or coordinate covalent bonding. An alternative and more contemporary definition of the term “chelate” requires that the metal ion be bonded to the ligand solely by coordinate covalent bonds forming the ring structure. In either case, both are definitions that describe a metal ion and a ligand forming a heterocyclic ring.

A chelate is a definite structure resulting from precise requirement of synthesis. Proper conditions must be present for chelation to take place, particularly under the more modern definition. These conditions include proper mole ratios of ligands to metal ions, pH and solubility of reactants. Generally, for chelation to occur, all components are dissolved in solution and are either ionized or of appropriate electronic configuration in order for coordinate covalent bonding and/or ionic bonding between the ligand and the metal ion to occur.

Chelation can be confirmed and differentiated from mixtures of components by infrared spectra through comparison of the stretching of bonds or shifting of absorption caused by bond formation. As applied in the field of mineral nutrition, there are two allegedly “chelated” products which are commercially utilized. The first is referred to as a “metal proteinate.” The American Association of Feed Control officials (AAFCO) has defined a “metal proteinate” as the product resulting from the chelation of a soluble salt with amino acids and/or partially hydrolyzed protein. Such products are referred to as the specific metal proteinate, e.g., copper proteinate, zinc proteinate, etc.

The American Association of Feed Control Officials (AAFCO) has also issued a definition for an amino acid chelate. It is officially defined as the product resulting from the reaction of a metal ion from a soluble metal salt with amino acids with a mole ratio of one mole of metal to one to three (preferably two) moles of amino acids to form coordinate covalent bonds. The average weight of the hydrolyzed amino acids must be approximately 150 and the resulting molecular weight of the chelate must not exceed 800. The products are identified by the specific metal forming the chelate, e.g., iron amino acid chelate, copper amino acid chelate, zinc amino acid chelate, etc.

An “amino acid chelate,” when properly formed, is a stable product having one or more five-membered rings formed by reaction between the carboxyl oxygen, and the α-amino group of an α-amino acid with the metal ion. Such a five-membered ring is defined by the metal atom, the carboxyl oxygen, the carbonyl carbon, the a-carbon and the α-amino nitrogen. The actual structure will depend upon the ligand to metal mole ratio and whether the carboxyl oxygen forms a coordinate covalent bond or an ionic bond with the metal ion. Generally, the ligand to metal mole ratio is at least 1:1 and is preferably 2:1 but, in certain instances, may be 3:1 or even 4:1. Most typically, an amino acid chelate may be represented at a ligand to metal ratio of 2:1 according to Formula 1 as follows: ##STR1##

In the above formula, the dashed lines represent coordinate covalent bonds, covalent bonds or ionic bonds and the solid lines represent covalent bonds or coordinate covalent bonds (i.e., bond between the metal and the α-amino groups). When R is H, the amino acid is glycine which is the simplest of the α-amino acids. However, R could be representative of any other of the other twenty or so naturally occurring amino acids derived from proteins. Regarding the sulfur-containing amino acids, when R is –CH 2 –CH 2 –S–CH 3, the amino acid is methionine, and when R is CH 2 –SH, the amino acid is cysteine. Further, two cysteine molecules bonded together by a disulfide bond form the amino acid cystine. Despite the different side chains, all of the amino acids have the same configuration for the positioning of the carboxyl oxygen and the α-amino nitrogen with respect to the metal ion. In other words, the chelate ring is defined by the same atoms in each instance.

The reason a metal atom can accept bonds over and above the oxidation state of the metal is due to the nature of chelation. For example, at the α-amino group of an amino acid, the nitrogen contributes to both of the electrons used in the bonding. These electrons fill available spaces in the d-orbitals forming a coordinate covalent bond. Thus, a metal ion with a normal valency of +2 can be bonded by four bonds when fully chelated. In this state, the chelate is completely satisfied by the bonding electrons and the charge on the metal atom (as well as on the overall molecule) is zero. As stated previously, it is possible that the metal ion be bonded to the carboxyl oxygen by either coordinate covalent bonds or ionic bonds. However, the metal ion is typically bonded to the α-amino group by coordinate covalent bonds only.

The structure, chemistry and bioavailability of amino acid chelates is well documented in the literature, e.g. Ashmead et al., Chelated Mineral Nutrition, (1982), Chas. C. Thomas Publishers, Springfield, Ill.; Ashmead et al., Intestinal Absorption of Metal Ions, (1985), Chas. C. Thomas Publishers, Springfield, Ill.; Ashmead et al., Foliar Feeding of Plants with Amino Acid Chelates, (1986), Noyes Publications, Park Ridge, N.J.; U.S. Pat. Nos. 4,020,158; 4,167,564; 4,216,143; 4,216,144; 4,599,152; 4,774,089; 4,830,716; 4,863,898 and others. Further, flavored effervescent mixtures of vitamins and amino acid chelates for administration to humans in the form of a beverage are disclosed in U.S. Pat. No. 4,725,427.

Zinc (Zn) is an essential trace mineral that is present in nearly all animal cells, including humans. However, zinc is highly concentrated in specialized areas of the brain, pancreas and adrenal gland. Further, zinc has structural, enzymatic and regulatory roles in the body of animals. In fact, well over 70 enzymes require zinc for activity, including RNA polymerases. Further, zinc is essential for proper growth, tissue repair, sexual maturity (i.e., reproductive organs, prostate functions and male hormone activity), reproductive performance, blood stability, protein synthesis, digestion and metabolism of phosphorus, and immunity.

The U.S. Recommended Daily Allowance (RDA) for zinc is as follows: for babies from birth to 1 year, 5 mg per day; for children 1 to 10 years, 10 mg per day; for men and boys 11 to 51 years, 15 mg per day; for women and girls 11 to 51 years, 12 mg per day; for pregnant women, 15 mg per day; for nursing mothers in the first 6 months, 19 mg per day; and for nursing mothers in the second 6 months, 16 mg per day.

Turning to the nourishment of non-human animals, the major sources of zinc approved by AAFCO for use in animal feed are zinc oxide and zinc sulfate. Zinc oxide is the most widely-used source of zinc in the animal feed industry because it has the highest zinc content and has been the most economical source of zinc on a per-unit basis. Zinc oxide suitable for animal use in feed is usually manufactured by the Waelz Kiln process. In the Waelz Kiln process, zinc-bearing ores are roasted, forming a zinc fume. The zinc fume is collected in a large collector and is densified. The very high temperatures used in this process drive off most of the residual heavy metals. Alternatively, zinc oxide for use in the feed industry may also be manufactured by the French process. The French process usually results in a higher zinc content (e.g. 78-80% zinc) than that produced by the Waelz Kiln process. However, the French process produces a powder that is more difficult to handle in animal feed mixes and is generally more expensive on a per-unit of zinc basis.

Zinc sulfate is also regularly used in animal feed products as an economic alternative to zinc oxide. Essentially, to make zinc sulfate, zinc is dissolved in sulfur-containing acid and spray dried. In either case, whether zinc oxide or zinc sulfate is used in an animal feed product, there are issues that work to prevent some of the zinc consumed by the animal from being bioavailable.

More recently, there has been a growing interest in compounds containing zinc and amino acids. For example, in U.S. Pat. No. 5,061,815, a zinc lysine complex is disclosed which also includes a halide, sulfate, phosphate, carbonate or acetate ion. This product is normally used in poultry and/or livestock rations. Particularly, the compound zinc lysine sulfate is commercially used and is alleged to provide rapid zinc absorption into the gastrointestinal tract of animals. The specific structure is comprised of one ion of zinc which is bound to one molecule of the amino acid lysine with an associated sulfate ion, i.e., 1:1 ligand to metal molar ratio.

Based upon what is known in the art presently, it would be useful to provide a zinc compound that is stable and is also more bioavailable than the inorganic zinc compounds previously known in the art. Further, it would be useful to provide a zinc compound that is formed by chelating zinc ions to a mixture glycine and a sulfur-containing amino acid, such that the weight percentage of zinc to the ligand may be more easily controlled and the zinc may be targeted to specific tissues or organs. These needs and others are fulfilled by the zinc amino acid chelate compositions of the present invention.

OBJECTS AND SUMMARY OF THE INVENTION

It is an object of the present invention to provide a zinc amino acid chelate formulation comprised of two amino acids (i.e., glycine and a sulfur-containing amino acid) such that a desired zinc content weight percentage may be achieved at from about a 1:1 to 2:1 amino acid ligand to metal molar ratio.

It is another object of the present invention to provide a stable and highly bioavailable zinc source for use in feed for livestock and poultry.

It is still another object of the present invention to provide a zinc source that is highly bioavailable such that the minimum daily requirement for zinc may more easily be met.

These and other objects may be accomplished by providing a zinc amino acid chelate formulation comprising zinc ions being chelated by an amino acid ligand mixture comprising glycine and a sulfur-containing amino acid wherein the ligand to zinc molar ratio is from about 1:1 to 2:1 and wherein the glycine to sulfur-containing amino acid molar ratio is between about 1:6 to 6:1.

DETAILED DESCRIPTION OF THE INVENTION

Before the present invention is disclosed and described, it is to be understood that this invention is not limited to the particular process steps and materials disclosed herein because such process steps and materials may vary somewhat. It is also to be understood that the terminology used herein is used for the purpose of describing particular embodiments only. The terms are not intended to be limiting because the scope of the present invention is intended to be limited only by the appended claims and equivalents thereof.

It must be noted that, as used in this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the content clearly dictates otherwise.

The term “chelate” is intended to cover both the traditional definition and the more contemporary definition as cited previously. Specifically, for purposes of the present invention, chelate is meant to include metal ions bonded to ligands forming heterocyclic rings. The bonds may be coordinate covalent, covalent and/or ionic at the carboxyl oxygen group. However, at the α-amino group, the bond is typically a coordinate covalent bond.

“Amino acid ligand mixture” is meant to include amino acids that are first mixed and then added to a zinc source as well as amino acids that are mixed in situ. In other words, it does not matter whether the amino acids are mixed prior to reaction with the zinc ions, mixed while in the presence of the zinc ions, or mixed after one of the amino acids has reacted with the zinc ions.

With this in mind, the present invention is drawn to a zinc amino acid chelate formulation comprising zinc ions being chelated by an amino acid ligand mixture comprising glycine and a sulfur-containing amino acid wherein the ligand to zinc molar ratio is from about 1:1 to 2:1 and wherein the glycine to sulfur-containing amino acid molar ratio is between about 1:6 to 6:1. Though the molar ratio of glycine to the sulfur-containing amino acid may be from about 1:6 to 6:1, it is preferred that the molar ratio of glycine to the sulfur-containing amino acid is from about 2:3 to 6:1, and most preferably from about 5:4 to 5:2.

As a practical matter, when the ligand to zinc molar ratio is about 2:1, the zinc ion and the amino acid ligand mixture will likely form a composition containing zinc bisglycinate, a zinc amino acid chelate having two sulfur-containing amino acid ligands, and a zinc amino acid chelate having one glycine ligand and one sulfur-containing amino acid ligand. When the ligand to zinc molar ratio is about 1:1, at least a portion of the chelates are zinc glycinates and at least a portion of the chelates are zinc amino acid chelates having a sulfur-containing amino acid ligand.

One of the other objectives of the present invention is to provide a compound where the average theoretical zinc content is from about 18 to 30% by weight for embodiments having a 2:1 ligand to metal molar ratio. However, it is preferred that the average theoretical zinc content is from about 21 to 27% by weight. Alternatively, for embodiments having a 1:1 ligand to metal molar ratio, the present invention provides a compound having an average theoretical zinc content from about 30 to 47% by weight. However, it is preferred that the average theoretical zinc content is from about 34 to 44% by weight. These weight ratios may be realized by reacting appropriate amounts of glycine and the sulfur-containing amino acid in an aqueous environment to form the zinc amino acid chelates disclosed herein. However, it is important to note that the weight percentages of both the 2:1 and the 1:1 embodiments described above are theoretical ranges which are based solely upon the zinc weight percentage as compared to the zinc amino acid chelate alone. In many circumstances, the actual weight percentage of zinc in the compound may be reduced due to the presence of other anions which may or may not be complexed to the amino acid chelate.

Regarding embodiments where an amino acid chelate having a 1:1 ligand to metal molar ratio is formed in accordance with the present invention, a sulfate anion will likely complex with the amino acid chelate. The general formula for such an amino acid chelate is [Zn(AA)SO 4 ]– H+ where AA is either a sulfur-containing amino acid or glycine, though both types of amino acid chelates, i.e., [Zn(Gly)SO 4 ]– H+ and [Zn(Met)SO 4 ]– H+, will be present in the composition.

Regarding embodiments where an amino acid chelate having a 2:1 ligand to metal molar ratio is formed in accordance with the present invention, any sulfate anion present in the composition will likely not complex with the amino acid chelate. However, each amino acid chelate molecule within the total composition will be comprised of zinc and two amino acid ligands where the ligands are selected from 1) two glycines, 2) one glycine and one sulfur-containing amino acid, or 3) two sulfur-containing amino acids. Thus, each individual chelate molecule will have one of three molecular weights. Therefore, when referring to the total zinc content by weight, the average zinc content over the entire composition will generally be described, either as a theoretical percentage or as an actual weight percentage.

The zinc of the amino acid chelates are preferably provided by one of many zinc sources such as zinc sulfate, zinc oxide, zinc chloride, zinc acetate, and combinations thereof, though other sources may be used as known by those skilled in the art. However, zinc sulfate is the most preferred zinc source. Additionally, fillers and/or drying agents including mineral oil, soy flour, wheat flour, rice flour, silica, maltodextrin, microcrystalline cellulose, and is others may also be added to the chelates of the present invention.

The following examples illustrate how the zinc amino acid chelates of the present invention are prepared and used. The following examples should not be considered as limitations of the present invention, but should merely teach how to make the best known amino acid chelates based upon current experimental data.

A mixture of 42.93 grams of zinc sulfate, 12 grams of methionine, and 30 grams of glycine were reacted in an aqueous environment for 60 minutes at a temperature of about 65 to 70° C. This reaction produced a zinc amino acid chelate having a ligand component to metal molar ratio of about 2:1, a theoretical average zinc content of about 26.8% by weight, and a glycine to methionine molar ratio of about 5:2. Due to the presence of the sulfate anion, the actual average zinc weight percentage was about 18.2%.

A mixture of 42.93 grams of zinc sulfate, 19 grams of cysteine, and 23.61 grams of glycine were reacted in an aqueous environment for 60 minutes a temperature of about 65 to 70° C. This reaction produced 63.5 grams of a zinc amino acid chelate having a ligand component to metal molar ratio of about 2:1, a theoretical average zinc content of about 26.6% by weight, and a glycine to cysteine molar ratio of about 5:4. Due to the presence of the sulfate anion, the actual average zinc weight percentage was about 18.1%.

A mixture of 42.93 grams of zinc sulfate, 6 grams of methionine, and 15 grams of glycine were reacted in an aqueous environment for 60 minutes at a temperature of about 65 to 70° C. This reaction produced a zinc amino acid chelate having a ligand component to metal molar ratio of about 1:1, a theoretical average zinc content of about 42.4% by weight, and a glycine to methionine molar ratio of about 5:2. Due to the presence of the sulfate anion, the actual average weight percentage of zinc was about 24.1%. Additionally, the product produced may be described by the general formula [Zn(AA)SO 4 ]– H+ where AA is either a methionine or glycine amino acid, though both varieties would be present in the overall composition.

A mixture of 42.93 grams of zinc sulfate, 9.5 grams of cysteine, and 11.8 grams of glycine were reacted in an aqueous environment for 60 minutes a temperature of about 65 to 70° C. This reaction produced 63.5 grams of a zinc amino acid chelate having a ligand component to metal molar ratio of about 1:1, an actual average zinc content of about 24% by weight, and a glycine to cysteine molar ratio of about 5:4. Additionally, the product produced may be described by the general formula [Zn(AA)SO 4 ]– H+ where AA is either a cysteine or glycine amino acid, though both varieties would be present in the final composition. In this example, the theoretical zinc content has not been calculated. However, the theoretical weight percentage for zinc in the amino acid chelate alone would be significantly higher than the actual weight percentage as disclosed above.

While the invention has been described with reference to certain preferred embodiments, those skilled in the art will appreciate that various modifications, changes, omissions, and substitutions can be made without departing from the spirit of the invention. It is intended, therefore, that the invention be limited only by the scope of the following claims.

Zinc Là Gì? Kẽm Zinc Có Tác Dụng Gì Đối Với Cơ Thể?

Zinc là gì có lẽ nhiều người không biết đến. Tuy nhiên đối với các chị em phụ nữ, thường xuyên chăm chút cho bản thân, làn da của mình thì sẽ biết tới vi chất này. Hiện nay, Zinc là chất có trong các loại mỹ phẩm, thực phẩm chức năng viên uống, nước uống để cải thiện sức khỏe, chăm sóc sắc đẹp. Ở bài viết này, ADIVA sẽ tổng hợp kiến thức Zinc là gì, triệu chứng khi cơ thể thừa Zinc hoặc thiếu Zinc như thế nào, nó có tác dụng gì với cơ thể chúng ta và những thực phẩm nào chứa Zinc cần bổ sung trong chế độ ăn uống hàng ngày.

Zinc là gì? Thực chất nó là tên viết tắt của kẽm. Xét về mặt hóa học thì Zinc là nguyên tố kim loại lưỡng tính. Còn xét về mặt sinh học thì Zinc là gì? Zinc là một chất khoáng vi lượng, nó cần thiết cho cơ thể con người.

Zinc là vi chất được bổ sung vào cơ thể dưới dạng các hợp chất trong thành phần các chất hữu cơ mà chúng ta vẫn hay ăn hàng ngày, chẳng hạn như kẽm oxit, kẽm sulfat, kẽm gluconat, hay kẽm acetat.

Kẽm có tác dụng gì đối với cơ thể

Sau khi biết được Zinc là gì, thì cùng ADIVA tìm hiểu rõ tác dụng của nó đối với cơ thể như thế nào? Zinc là thành phần quan trọng, không thể thiếu trong cơ thể của chúng ta, nó giúp xương khỏe mạnh để nâng đỡ toàn bộ cơ thể và nhiều công dụng khác.

+ Giúp xương chắc khỏe hơn.

+ Giúp tóc chắc khỏe, mềm mịn hơn.

+ Tốt cho mắt, giúp cơ bắp mạnh mẽ.

+ Cân bằng nội tiết tố cho cơ thể.

+ Kẽm hỗ trợ tăng trưởng ở nam giới

+ Hữu ích với hệ tiêu hóa, tiểu đường, ung thư, giảm viêm và các bệnh lý mãn tính,…

Như vậy Zinc là chất vô cùng quan trọng với cơ thể của chúng ta, cần bổ sung đúng cách để chăm sóc sức khỏe một cách tốt nhất.

Dấu hiệu thiếu Zinc là gì

+ Tự nhiên bị rụng tóc.

+ Móng giòn dễ gãy và có đốm trắng

+ Bị loét miệng.

+ Răng kém sáng bóng

+ Mụn hoặc những vấn đề khác trên da

+ Xương yếu.

+ Mất thính lực

+ Không tăng trưởng chiều cao

+ Mất mùi vị

+ Bị nhiễm trùng

+ Mắc bệnh mãn tính.

Đây là dấu hiệu cơ thể đang bị thiếu Zinc cần bổ sung ngay.

Dấu hiệu cơ thể bị dư thừa Zinc là gì?

Sự thừa kẽm có thể dẫn đến các triệu chứng khác chẳng hạn:

+ Bạn cảm thấy có vị kim loại trong miệng

+ Bị nhức đầu

+ Thậm chí bị nôn mửa và tiêu chảy.

Zinc là gì, biểu hiện thiếu thừa Zinc cũng như công dụng của nó như thế nào được chia sẻ rõ như trên, các bạn hãy lưu lại khi cần thì tìm hiểu.

Kẽm có trong những thực phẩm nào?

Bạn có thể tự bổ sung Zinc bằng các thực phẩm tự nhiên hoặc thực phẩm chức năng cho cơ thể bù đắp lượng Zinc đang hụt.

Một số thực phẩm giàu Zinc như ngũ cốc, mầm lúa mì, hạt bí ngô, hạt vừng, thịt, động vật có vỏ, trái cây, các loại rau, sô cô la đen, rau chân vịt, nấm, các loại hạt, con hầu,…

Với các sản phẩm Collagen ADIVA, trong thành phần Collagen này chứa Zinc (Citrate): 0.8mg, bổ sung hàm lượng Zinc vừa đủ mỗi ngày trong 1 lọ Collagen. Collagen ADIVA không chỉ giúp làm đẹp da, mà còn chứa nhiều dưỡng chất cần thiết giúp chăm sóc sức khỏe một cách tối ưu.

Do đó, bổ sung tinh chất ADIVA cũng là một giải pháp cung cấp Zinc cho cơ thể hiệu quả.

Mọi thắc mắc vui lòng liên hệ ngay hotline: 1900 555 552 để được chuyên viên tư vấn.

Zinc Oxide Là Gì? Vì Sao Zinc Oxide Được Sử Dụng Nhiều?

Bạn có thể thấy Zinc Oxide xuất hiện ở rất nhiều trong bảng thành phần của các loại kem chống nắng. Vậy thực chất Zinc Oxide là gì?

Zinc Oxide còn được gọi là kẽm oxit hay Znc White, Calamine. Công thức hóa học của Zinc Oxide là ZnO. Nó tồn tại ở dạng bột màu trắng hoặc không màu, không mùi. Nhiệt độ nóng chảy là 1975 độ C. Theo các nghiên cứu, Zinc Oxide an toàn và lành tính với da khi tiếp xúc trực tiếp.

Kẽm Oxit (công thức hóa học: ZnO, trước đây, do được dùng để làm chất màu trắng nên được gọi là kẽm trắng, hay kẽm hoa (là chất bột mịn sau khi ngưng tụ kẽm ở trang thái hơi). Hiện nay, kẽm trắng là thuật ngữ để chỉ ZnO điều chế bằng cách đốt cháy kẽm kim loại.

Ngành công nghiệp hóa chất: Zinc Oxide được ứng dụng để sản xuất cao su, sản xuất bê tông, sản xuất thức ăn chăn nuôi gia súc, gia cầm, thức ăn cho thủy hải sản…

Y tế: Zinc Oxide được dùng để dưỡng da và điều trị nha khoa, sản xuất thuốc mỡ khử trùng, kem bôi.

Ngành mỹ phẩm: Zinc Oxide được dùng trong sản xuất kem chống nắng, kem dưỡng da…

Ứng dụng trong khử khuẩn: Vải bông, cao su, bao bì của thực phẩm…

Ngành công nghiệp điện tử, công nghiệp luyện kim, xi mạ, luyện đồng, luyện bạc, sản xuất gốm, sứ, gạch men…

Zinc Oxide được nghiên cứu và ứng dụng trong nhiều lĩnh vực của đời sống. Chúng ta có thể kể đến một số những lĩnh vực gồm:

Về cơ bản Zinc Oxide an toàn với da khi tiếp xúc. Vì vậy đảm bảo không gây kích ứng hay các tác dụng phụ nào cho da.

Vậy tác dụng của Zinc Oxide là gì?

Zinc Oxide được ứng dụng nhiều trong các lĩnh vực khác nhau của đời sống. Tuy nhiên chúng ta sẽ tìm hiểu cụ thể hơn về tác dụng của Zinc Oxide trong mỹ phẩm. Cụ thể là kem chống nắng. Lý do tại sao thành phần này lại được lựa chọn góp mặt trong kem chống nắng đến thế?

Zinc Oxide chính là một trong những thành phần được nhiều người lựa chọn sản xuất kem chống nắng. Thành phần này đã được nghiên cứu và chỉ ra tác dụng chống nắng cực tốt. Zinc Oxide giúp ngăn chặn được tia UVA, tia UVB. Nhờ đó nó có thể bảo vệ làn da một cách tuyệt đối. Đó là lý do những loại kem chống nắng cao cấp thường hay góp mặt Zinc Oxide.

Các loại kem chống nắng hóa học không chứa Zinc Oxide sẽ phải cần từ 15 – 20 bôi trước khi ra ngoài. Chúng cần thời gian thẩm thấu sâu vào bên trong da để phát huy tác dụng chống nắng. Thế nhưng với loại kem chống nắng từ Zinc Oxide thì có thể hoạt động được ngay. Tuy nhiên thì vẫn khuyến khích nên bôi theo thời gian từ 15 – 20 phút để đảm bảo hiệu quả.

Nhờ khả năng chống lại hoàn toàn được tia UV mà Zinc Oxide thật sự như một “lá chắn thép”. Nó giúp loại bỏ tia UV cũng đồng nghĩa loại bỏ tác nhân gây lão hóa da. Ngăn ngừa được các tác nhân khiến da bị thâm, nám, sạm và xỉn màu. Vì thế nên việc lựa chọn và sử dụng kem chống nắng có thành phần Zinc Oxide rất tuyệt vời. Nó sẽ giúp bạn có thể ngăn ngừa được mọi khuyết điểm của da trong tình trạng tiếp xúc với ánh nắng.

Làn da của chúng ta khi được bổ sung thêm Zinc Oxide sẽ luôn tươi trẻ, rạng ngời. Nhờ đó sẽ luôn mang lại sự an toàn và hiệu quả khi chống nắng.

Sẽ thật tuyệt khi lớp kem chống nắng thoa lên da không bị lô vân kem. Bạn sẽ chẳng thấy vệt kem trắng xuất hiện sau khi bôi. Chính là nhờ Zinc Oxide. Thành phần trong kem chống nắng có khả năng giúp da sáng và đều màu hơn ngay lập tức. Làn da được cải thiện, che khuyết điểm nhanh chóng nếu có vết thâm, tàn nhang, nám…

Tác dụng tiếp theo của Zinc Oxide chính là khả năng kháng khuẩn. Nhờ đó thành phần này giúp hạn chế được tình trạng viêm nhiễm trên da. Zinc Oxide rất dịu nhẹ, không gây kích ứng và không gây mụn. Cực kỳ lành tính với làn da của chúng ta. Thậm chí làn da bị mụn hay da nhạy cảm vẫn có thể sử dụng được kem chống nắng có Zinc Oxide.

Zinc Oxide thật sự là thành phần quan trọng của kem chống nắng. Không chỉ có tác dụng trên, nó còn giúp hạn chế tình trạng viêm tắc lỗ chân lông. Nhờ đó làn da luôn thông thoáng, hạn chế tác nhân gây mụn tối ưu.

Với những tác dụng trên của Zinc Oxide, không khó hiểu tại sao 1 hãng kem chống nắng nổi tiếng như EltaMD lại lựa chọn đưa vào EltaMD UV Clear Broad-Spectrum SPF 46. Vừa có khả năng chống nắng hoàn hảo lại vừa giúp cải thiện, chăm sóc da.

Hypurin Bovine Protamine Zinc (Protamine Zinc Insulin)

What is it used for? How does it work?

Hypurin bovine protamine zinc vials contain protamine zinc insulin. This type of insulin is obtained from cow pancreas and mixed with zinc and protamine to produce long-acting insulin crystals. It is used to treat diabetes.

People with diabetes have a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar (glucose) in the blood.

People with type 1 diabetes need to have injections of insulin to control the amount of glucose in their bloodstream. Insulin injections act as a replacement for natural insulin and allow people with diabetes to achieve normal blood glucose levels.

The insulin works in the same way as natural insulin, by binding to insulin receptors on cells in the body. Insulin causes cells in the liver, muscle and fat tissue to increase their uptake of glucose form the bloodstream. It also decreases the production of glucose by the liver, and has various other effects that lower the amount of glucose in the blood.

The type of insulin in Hypurin bovine protamine zinc is called protamine zinc insulin. This is known as a long-acting insulin. When injected under the skin it starts working after approximately four to six hours, and its effects last for 24 to 36 hours. This helps to control blood glucose throughout the day.

Protamine zinc insulin is normally used in combination with a short-acting insulin, which is given before meals to control the spikes in blood sugar levels that occur after eating.

It is important to monitor your blood glucose regularly and adjust your insulin dose as required. Your doctor or diabetic team will explain how to do this. Keeping your blood glucose level as close to normal as possible, and not too high or too low, significantly reduces the risk of developing late-stage diabetic complications.

How do I use it?

Your doctor or diabetes specialist will teach you how to administer your insulin injections correctly. Make sure you understand what to do and ask questions if you don’t.

Hypurin bovine protamine zinc injections are usually given under the skin of the upper arms, thighs, buttocks, or abdomen. You should take care to make sure that the injection does not enter a blood vessel. The injection may start to start to work at different speeds depending on the site you use and various other factors, such as if you have been doing exercise. In general, injections into the abdomen start to work quicker than those given in other areas. You shouldn’t massage the injection area after administering an injection.

Each time you inject your insulin make sure you use a different site. This helps to prevent the skin thickening and pitting, which can occur if the injection is repeatedly given in the same site.

You should measure your blood sugar levels every day when using insulin injections. The dose you need to inject each time will depend on your blood sugar levels, what you are going to eat and if you have been doing or will be doing exercise. Control of blood sugar is an individual process and your diabetes specialist will help you to understand what is required.

Your insulin requirements may increase when you are ill, especially if you have an infection or fever. Your insulin dose may also need adjusting during periods of emotional disturbance, or if you increase your physical activity or change your usual diet. Insulin requirements may be reduced if you have impaired kidney or liver function. Discuss this with your doctor or diabetes nurse to make sure you optimise control of your blood sugar.

Warning!

This medicine must not be injected into a vein (intravenously).

Your ability to concentrate or react may be reduced if you have low blood sugar, and this can cause problems driving or operating machinery. You should take precautions to avoid low blood sugar when driving – discuss this with your doctor.

People with diabetes who are on insulin should only drink alcohol in moderation and accompanied by food. This is because alcohol can make your warning signs of low blood sugar less clear, and can cause delayed low blood sugar, even several hours after drinking.

People with diabetes who smoke normally need more insulin, as smoking reduces the amount of insulin that is absorbed into the blood from an injection under the skin. If you give up smoking, you may subsequently need a reduction in your insulin dose. Discuss this with your doctor. (If you are diabetic giving up smoking is one of the most important things you can do, because it will vastly reduce your risk of complications like heart disease and circulatory problems.)

Not to be used in

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

Insulin does not cross the placenta and provides no risk to the developing baby. Blood sugar levels need to be maintained as stable as possible during pregnancy, and you should consult your diabetic specialist to discuss how to achieve this. Your insulin requirements are likely to decrease in the first trimester and subsequently increase in the second and third trimesters. Discuss this with your doctor.

There is no risk to nursing infants from insulin taken by the mother. However, your insulin dose may need to be decreased during breastfeeding. Discuss this with your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Low blood glucose level (hypoglycaemia).

Redness, swelling or itching at the injection site.

Skin thickening or pitting (lipodystrophy) if injection given too frequently into the same site.

Allergic reaction (hypersensitivity), such as skin rash or itching, hives, chest tightness, shortness of breath or severe allergic reactions such as anaphylaxis.

The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

The following medicines may decrease blood sugar levels. If you start treatment with any of these your insulin dose may therefore need decreasing:

ACE inhibitors, eg captopril (these can sometimes cause unpredictable drops in blood sugar)

anabolic steroids, eg testosterone, nandrolone, stanozolol

antidiabetic medicines taken by mouth

disopyramide

fibrates, eg gemfibrozil

fluoxetine

MAOI antidepressants, eg phenelzine

octreotide

large doses of salicylates, eg aspirin (small pain relieving doses do not normally have this effect).

Beta-blockers, eg propranolol (including eye drops containing beta-blockers) can mask some of the signs of low blood sugar, such as increased heart rate and tremor. They also prolong episodes of low blood sugar and impair recovery back to normal glucose levels.

The following medicines may increase blood glucose levels. If you start treatment with any of these your insulin dose may therefore need increasing:

some antipsychotic medicines, eg chlorpromazine, olanzapine

corticosteroids, eg hydrocortisone, prednisolone

danazol

diuretics, especially thiazide diuretics, eg bendroflumethiazide

isoniazid

lithium

protease inhibitors, eg ritonavir

somatropin (human growth hormone).

Oestrogens and progestogens, such as those contained in oral contraceptives, may affect blood sugar levels, and women taking these may need small adjustments up or down in their insulin dose.

How do I store Hypurin bovine protamine zinc?

Vials: Before use, vials should be stored in a refrigerator at 2-8°C. Do not freeze. Keep the vial in the outer carton in order to protect from light. Once in use, the vial should be kept out of the fridge, below 25°C. It can be used for up to 28 days. Again, keep it in the outer carton to protect it from light.

Make sure all medicines are kept out of the reach of children and avoid exposing them to excessive heat or direct sunlight.

Other medicines containing the same active ingredient

There are many other forms of insulin available; you can read about these here.

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